Expression of the Antisense-to-Latency Transcript Long Noncoding RNA in Kaposi's Sarcoma-Associated Herpesvirus
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The “ ” ( ) transcript NF - ĸB interacting long noncoding RNA NKILA is antisense to cancer - associated gene PMEPA
This correspondence concerns a recent publication in by Liu et al. Cancer Cell who analyzed a long noncoding RNA (lncRNA) that they designated “ ”. NKILA Liu et al. found that (1) is upregulated by immunostimulants, (2) has a NKILA promoter with an NF-ĸB binding motif, (3) can bind to the p65 protein of the NF-ĸB transcription factor and then interfere with phosphorylation of IĸBα, and (4) nega...
متن کاملThe “ NF-ĸ B interacting long noncoding RNA” ( NKILA) transcript is antisense to cancer-associated gene PMEPA1
This correspondence concerns a recent publication in Cancer Cell by Liu et al. (1) who analyzed a long noncoding RNA (lncRNA) that they designated " NKILA". Liu et al. found that NKILA (1) is upregulated by immunostimulants, (2) has a promoter with an NF-ĸB binding motif, (3) can bind to the p65 protein of the NF-ĸB transcription factor and then interfere with phosphorylation of IĸBα, and (4) ...
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Animal cells possess thousands of long non-coding (lnc) RNAs, such as antisense noncoding RNA in the INK4 locus (ANRIL) , which have regulatory roles in the cells’ molecular mechanisms, including X-chromosome inactivation, and developmental processes. These lnc RNAs are known to influence the extensive spectrum of age-related disorders. Accordingly, there is evidence for the role of...
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Kaposi's sarcoma-associated herpesvirus (KSHV) is an oncogenic γ-herpesivrus, the causative agent of Kaposi's sarcoma and body cavity lymphomas. During infection KSHV produces a highly abundant long non-coding polyadenylated RNA that is retained in the nucleus known as PAN RNA. Long noncoding RNAs (lncRNA) are key regulators of gene expression and are known to interact with specific chromatin m...
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Latency-associated nuclear antigen (LANA) is encoded by the Kaposi's sarcoma (KS)-associated herpesvirus (KSHV) open reading frame 73. LANA is expressed during latent KSHV infection of cells, including tumor cells, such as primary effusion lymphoma, KS and multicentric Castleman's disease. Latently infected cells have multiple extrachromosomal copies of covalently closed circular KSHV genomes (...
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ژورنال
عنوان ژورنال: Journal of Virology
سال: 2017
ISSN: 0022-538X,1098-5514
DOI: 10.1128/jvi.01698-16